How is Adipogenesis related to obesity?

How is Adipogenesis related to obesity?

However, adipocyte hyperplasia (adipogenesis) is now known to contribute to the increased adipose tissue mass of obesity. Animal studies suggest that hyperplasia occurs in 2 steps: an increase in numbers of preadipocytes and differentiation of preadipocytes into mature (adipokine-secreting) adipocytes.

Why is Adipogenesis important?

However, adipogenesis is a complex physiological process, necessary to sequester lipids effectively to avoid lipotoxicity in other tissues, like the liver, heart, muscle, essential for maintaining metabolic homeostasis and has a crucial role as a component of the innate immune system, far beyond than only being an ...

How does adipose tissue cause obesity?

Dysfunctional adipose tissue is characterized by enlarged adipocytes, vascular rarefaction, increased inflammatory cell infiltrate and the appearance of crown-like structures. In addition to macrophages, other myeloid cells, such as neutrophils and mast cells, contribute to adipose tissue dysfunction in obesity.

Can obesity cause inflammation in adipose tissue?

Obesity causes low-grade chronic inflammation. Adipose tissue, in addition to its function of storing energy reserves in the form of triglycerides, has important functions as an endocrine organ, producing a variety of molecules called adipocytokines such as IL-1, IL-6, IL-8, IFNγ, TNFα, leptin and resistin.

How do you increase Adipogenesis?

Niacin. Niacin is the most effective for increasing HDL levels and decreases total cholesterol, LDL, triglyceride synthesis, and fatty acid re-esterification. It stimulates adipogenesis throughout increasing PPARγ, FABP4, adiponectin, and leptin expression in 3T3-L1 cells.

What is adipocyte hypertrophy?

Adipocyte hypertrophy is a recognized feature of dysfunctional adipose tissue that is associated with increased cellular stress, decreased metabolic flexibility, and systemic diabetes. The mechanisms that regulate hypertrophy are unclear.

What does lipogenesis mean?

Definition of lipogenesis : the formation of fat specifically : the formation of fatty acids from acetyl coenzyme A in the living body and especially in adipose tissue and the liver.

What cells are affected by obesity?

Adipose tissue-resident immune cells, including T cells (5), B cells (6), macrophages (7), and dendritic cell (DC) subsets (8, 9), are dysregulated in the context of obesity and are associated with the development of a disturbed immune system and progression of the disease.

What is the major metabolic function of adipose tissue?

The adipose tissue is a central metabolic organ in the regulation of whole-body energy homeostasis. The white adipose tissue functions as a key energy reservoir for other organs, whereas the brown adipose tissue accumulates lipids for cold-induced adaptive thermogenesis.

What is the relationship between obesity and inflammation?

There is an association between increased weight gain and increased inflammation. More weight can mean more inflammation. However, reducing excess weight also tends to mean less inflammation. Gut inflammation may also be a contributing factor and can lead to weight gain.

What is the relationship between obesity and adipogenesis?

• Adipogenesis and metabolic health Obesity is characterized by increased adipose tissue mass and has been associated with a strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public health issue of major proportion. The expansion of adipose depots can be driven either by the increase in adipocyte size …

What is the pathophysiology of obesity?

• Obesity is characterized by increased adipose tissue mass and has been associated with a strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public health issue of major proportion. The expansion of adipose depots can be driven either by the increase in adipocyte size … Adipogenesis and metabolic health

Is there a link between microRNAs and obesity?

• Emerging evidence is connecting microRNAs (miRNAs) dysregulation with adipogenesis and obesity. Alteration in miRNAs expression could result in changes in the pattern of genes controlling a range of biological processes including inflammation, lipid metabolism, insulin resistance and adipogenesis.

What drives the expansion of adipose depots?

• The expansion of adipose depots can be driven either by the increase in adipocyte size … Obesity is characterized by increased adipose tissue mass and has been associated with a strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public health issue of major proportion.